Tyck till om SwePub Sök
här!
Search: WFRF:(Jansson Per Anders)
> Johansson Lars
> Carlsson Per Ola >
The Positron Emissi...
The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas
-
- Eriksson, Olof (author)
- Uppsala universitet,Plattformen för preklinisk PET
-
- Espes, Daniel (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
- Selvaraju, Ram K (author)
- Uppsala universitet,Plattformen för preklinisk PET
-
show more...
-
- Jansson, Emma (author)
- Uppsala universitet,Enheten för radiologi
-
- Antoni, Gunnar (author)
- Uppsala universitet,Enheten för onkologi
-
- Sörensen, Jens (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
-
- Lubberink, Mark (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
-
- Biglarnia, Alireza (author)
- Uppsala universitet,Transplantationskirurgi
-
- Eriksson, Jan W (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
-
- Sundin, Anders (author)
- Uppsala universitet,Enheten för radiologi
-
- Ahlström, Håkan (author)
- Uppsala universitet,Enheten för radiologi
-
- Eriksson, Barbro (author)
- Uppsala universitet,Endokrin tumörbiologi
-
- Johansson, Lars (author)
- Uppsala universitet,Enheten för radiologi
-
- Carlsson, Per-Ola (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
-
- Korsgren, Olle (author)
- Uppsala universitet,Klinisk immunologi
-
show less...
-
(creator_code:org_t)
- 2014-09-15
- 2014
- English.
-
In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:10, s. 3428-3437
- Related links:
-
https://diabetes.dia...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- In humans a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of beta cells, with healthy volunteers (HV).C-peptide negative (i.e. insulin-deficient) T1D subjects (n=10) and HV (n=9) underwent dynamic Positron Emission Tomography with the radiolabeled serotonin precursor [(11)C]5-Hydroxy-Tryptophan ([(11)C]5-HTP).A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HV, with large inter-individual variation. A substantial and highly significant reduction (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most evident in the corpus and caudal regions of the pancreas where beta-cells normally are the major constituent of the islets.[(11)C]5-HTP retention in the pancreas was reduced in T1D compared to non-diabetic subjects. Accumulation of [(11)C]5-HTP in the pancreas of both HV and subjects with T1D were in agreement with previously reported morphological observations on the beta cell volume implying that [(11)C]5-HTP retention is a useful non-invasive surrogate marker for the human endocrine pancreas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Diabetes
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Eriksson, Olof
-
Espes, Daniel
-
Selvaraju, Ram K
-
Jansson, Emma
-
Antoni, Gunnar
-
Sörensen, Jens
-
show more...
-
Lubberink, Mark
-
Biglarnia, Alire ...
-
Eriksson, Jan W
-
Sundin, Anders
-
Ahlström, Håkan
-
Eriksson, Barbro
-
Johansson, Lars
-
Carlsson, Per-Ol ...
-
Korsgren, Olle
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Other Basic Medi ...
- Articles in the publication
-
Diabetes
- By the university
-
Uppsala University